1. Endogenous oncogenic K-rasG12D stimulates proliferation and ...
Activating mutations in the ras oncogene are not considered sufficient to induce abnormal cellular proliferation in the absence of cooperating oncogenes.
Activating mutations in the ras oncogene are not considered sufficient to induce abnormal cellular proliferation in the absence of cooperating oncogenes. We demonstrate that the conditional expression of an endogenous K-rasG12D allele in murine embryonic fibroblasts causes enhanced proliferation and partial transformation in the absence of further genetic abnormalities. Interestingly, K-rasG12D-expressing fibroblasts demonstrate attenuation and altered regulation of canonical Ras effector signaling ...
2. Lifu Wang's Poker Statistics: Hendon Mob Poker Database
Lifu Wang's Statistics ... Taiwan Lifu Wang. Total Live Earnings $108. Best Live Cash $108. Connect with Lifu ... Daytona Beach GAPT Mega Rush, Daytona Beach. 28 ...
Total life earnings: $108. Latest cash: $108 on 17-Jun-2024. See Lifu Wang's full profile.
3. BBB opening with focused ultrasound in nonhuman primates and ... - NCBI
19 apr 2023 · Transcranial LIFU with magnetic resonance imaging (MRI) guidance was applied in six monkeys (M1 to M6). Initially, LIFU was performed in two ...
Intracerebral vector delivery in nonhuman primates has been a major challenge. We report successful blood-brain barrier opening and focal delivery of adeno-associated virus serotype 9 vectors into brain regions involved in Parkinson’s disease using ...
4. Focused ultrasound-induced cell apoptosis for the treatment of tumours
21 aug 2024 · Comparison of the synergistic effect of lipid nanobubbles and SonoVue microbubbles for high intensity focused ultrasound thermal ablation of tumors.
Cancer is a serious public health problem worldwide. Traditional treatments, such as surgery, radiotherapy, chemotherapy, and immunotherapy, do not always yield satisfactory results; therefore, an efficient treatment for tumours is urgently needed. As a convenient and minimally invasive modality, focused ultrasound (FUS) has been used not only as a diagnostic tool but also as a therapeutic tool in an increasing number of studies. FUS can help treat malignant tumours by inducing apoptosis. This review describes the three apoptotic pathways, apoptotic cell clearance, and how FUS affects these three apoptotic pathways. This review also discusses the role of thermal and cavitation effects on apoptosis, including caspase activity, mitochondrial dysfunction, and Ca2+ elease. Finally, this article reviews various aspects of FUS combination therapy, including sensitization by radiotherapy and chemotherapy, gene expression upregulation, and the introduction of therapeutic gases, to provide new ideas for clinical tumour therapy.
5. Exosomes Derived from Dendritic Cells Treated with Schistosoma ...
13 sep 2017 · These results indicate that SEA-treated DC exosomes attenuate the severity of acute DSS-induced colitis mice more effectively than DC exosomes.
Exosomes are 30–150 nm small membrane vesicles that are released into the extracellular medium via cells that function as a mode of intercellular communicati...
6. Thyroid Cancer Detection by Ultrasound Molecular Imaging with ...
The ultrasound molecular imaging with NPs-SHP2 was performed in thyroid tumour bearing mice. After NPs-SHP2 injection followed by LIFU irradiation (1.40 w/cm2 ...
Contrast-enhanced ultrasound imaging has been widely used in the ultrasound diagnosis of a variety of tumours with high diagnostic accuracy, especially in patients with hepatic carcinoma, while its application is rarely reported in thyroid cancer. ...
7. Carrier lifetime enhancement in halide perovskite via remote epitaxy
12 sep 2019 · The study provides an avenue to develop free-standing halide perovskite film with low dislocation density and improved carried dynamics.
Crystallographic dislocation has been well-known to be one of the major causes responsible for the unfavorable carrier dynamics in conventional semiconductor devices. Halide perovskite has exhibited promising applications in optoelectronic devices. However, how dislocation impacts its carrier dynamics in the ‘defects-tolerant’ halide perovskite is largely unknown. Here, via a remote epitaxy approach using polar substrates coated with graphene, we synthesize epitaxial halide perovskite with controlled dislocation density. First-principle calculations and molecular-dynamics simulations reveal weak film-substrate interaction and low density dislocation mechanism in remote epitaxy, respectively. High-resolution transmission electron microscopy, high-resolution atomic force microscopy and Cs-corrected scanning transmission electron microscopy unveil the lattice/atomic and dislocation structure of the remote epitaxial film. The controlling of dislocation density enables the unveiling of the dislocation-carrier dynamic relation in halide perovskite. The study provides an avenue to develop free-standing halide perovskite film with low dislocation density and improved carried dynamics. Crystallographic dislocation has proven harmful to the carrier dynamics in conventional semiconductors but it is unexplored in metal halide perovskites. Here Jiang et al. grow remote epitaxial perovskite films on graphene with density-controlled dislocations and confirm their negative impact.
8. Oridonin inhibits growth and induces apoptosis of human neurocytoma ...
18 jun 2018 · Weiguang Wang; Lifu Wei; Shan Gao; Yingge Wang. View Affiliations. Affiliations: Department of Anatomy, College of Medicine, Yangzhou University ...
Central neurocytoma (CN) is a rare periventricular tumor of the central nervous system in young adults. Typically, patients with CN exhibit a favorable prognosis, but in certain cases the clinical course is more aggressive. Therefore, investigating effective therapeutic approaches is important. Oridonin has attracted attention due to its antitumor activities. However, the role of oridonin in tumorigenesis and progression remains unknown. The present study examined the antitumor function of oridonin in CN cells, and investigated the underlying molecular mechanism. An MTT assay suggested that treatment with oridonin was able to significantly inhibit the proliferation of CN cells. The annexin V‑fluorescein isothiocyanate/propidium iodide assay and western blot analysis demonstrated that oridonin was able to induce apoptosis and alter the expression of apoptosis‑associated proteins by downregulating anti‑apoptotic protein, B‑cell lymphoma‑2 (Bcl‑2), and upregulating pro‑apoptosis proteins, Bcl‑2‑like protein 4, cleaved caspase‑3 and cleaved poly(ADP‑ribose) polymerase 1. Subsequently, the Wnt/β‑catenin signaling pathway was examined. Western blot analysis indicated that oridonin markedly decreased the expression of β‑catenin, cyclin D1 and v‑myc avian myelocytomatosis viral oncogene homolog. Furthermore, β‑catenin was silenced by small interference RNA or overexpressed in CN cells, and the effect on cell proliferation was examined. The results indicated that silencing of β‑cateni...
9. Response to Comment on "A Dynamic Network ... - FreiDok plus
Jameel, Zhiyong Wang, and Tony Hunter. ... Wang, Lifu, Thurl E. Harris, and John C. Lawrence ... “PKBα/Akt1 Acts Downstream of DNA-PK in the DNA Double-Strand Break ...
Science Signaling -
10. Johns Hopkins Discovery Awards: 2020 Awardees - VPR at JHU
... Wang (Engineering), Ulrich Mueller (Medicine & Arts & Sciences) & Daniel Sun ... Beach (Medicine) & Mark Dredze (Engineering). How Natural Single-guide ...
In 2020, 41 Discovery Awards were given to interdisciplinary faculty teams across eleven units of Johns Hopkins. From utilizing machine learning to optimize stroke critical care to tackling CO2 emissions to addressing food insecurity, these Discovery Awards are solving complex problems and expanding the horizons of knowledge.
